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You could use CONTAM to perform simulations to determine infiltration rates using the leakage rate obtained from the blower door test. Further, you can adjust the wind speed modifier based on terrain. NIST provides another tool to export the CONTAM infiltration results to a related EnergyPlus model to populate the ZoneInfiltration:DesignFlowRate object and schedule it to adjust infiltration based on the CONTAM results. You can verify blower door results within the CONTAM model with the Building Pressurization Test mode of the program.

I realize that this adds another tool to your simulation workflow, but if you know you will use this method before you create your E+ model, then you can generate the E+ IDF file from the CONTAM project.

The above information is detailed in documentation provided by NIST:

CONTAM to EnergyPlus infiltration - http://dx.doi.org/10.6028/NIST.TN.1873

Commercial building infiltration - http://www.nist.gov/manuscript-publication-search.cfm?pub_id=917135

Exporting CONTAM to EnergyPlus - http://www.nist.gov/manuscript-publication-search.cfm?pub_id=918338